10 results
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
: Inflammatory eye ... Behcet disease) Differential ... #diagnosis #management ... #signs #symptoms ... #rheumatology #
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS

What Is IRIS?
	• A state of hyperinflammatory response that
Reconstitution Inflammatory Syndrome ... skin lesions, ocular ... weeks for most OI ... #Differential # ... Diagnosis #Management
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Dehydration • Symptoms ... WBC >100k, + lab signs ... Lysis of tumor cells ... #TLS #diagnosis ... #management #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Presentation - Systemic Symptoms ... Arthralgias • Eye ... purpura: strong sign ... Eye -> retinopathy ... #diagnosis #rheumatology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Release from blast cells ... : >3 symptoms, or ... initiation • Differential ... #management #hematology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Presentation: Systemic Symptoms ... Arthralgias • Eye ... purpura: Strong sign ... • Progressive symptoms ... #Diagnosis #Rheumatology
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
ingestion • B symptoms ... lymph node biopsy (diagnostic ... Immunohistochemical studies (to differentiate ... classification #hematology ... #oncology #management
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Diagnosis: • Dry ... eyes • Salivary ... gland) biopsy • Ocular ... Nephrogenic DI Hematologic ... Diagnosis #Management
Hemophagocytic Lymphohistiocytosis (HLH)

High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... hyperinflammatory syndrome ... Presentation • Common Signs ... and Symptoms: ... #Management #Hematology
Relapsing Polychondritis

What is it?
Recurrent inflammation of the cartilage in the body (Autoimmune disorder)

Who?
• Most frequently: 40
ethnicities Symptoms ... + Nonspecific symptoms ... chondritis • Ocular ... vessels (aorta) • Eyes ... #diagnosis #management