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diagnosis hematology oncology differential leukemia chronic differentiation hemeonc hemophagocytic hlh immune inflammatory lymphocytic lymphohistiocytosis mds myelodysplasia myelodysplastic reconstitution sarcoidosis syndromes
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
lymphadenopathy • Blast cells ... Rapidly rising blast cells ... : Granulocytic cells ... organs When Cancer Cells ... ) CLL Symptoms:
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... Physical Exam/Signs ... cells can infiltrate ... smear: Smudge cells ... or basket cells
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
caused by blood cells ... age 70 years Symptoms ... transformation to AML ... progression to AML ... #diagnosis #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... in APML Epidemiology ... Release from blast cells ... Diagnosis: >3 symptoms ... #management #hematology
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
Reconstitution Inflammatory Syndrome ... What Is IRIS ... increase in CD4+ cells ... weeks for most OI ... Differential #Diagnosis #Management
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Diagnosis and Management ... -year survival is ... tissue: Epithelioid cells ... Sarcoidosis #Diagnosis #Management ... #Signs #Symptoms
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Arthralgias • Eye ... purpura: Strong sign ... Multinucleated giant cells ... • Progressive symptoms ... Differential #Diagnosis #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
Presentation • Common Signs ... and Symptoms: ... function of NK cells ... and CD8+ T cells ... #Hematology #HemeOnc
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
overgrowth of cells ... and the systemic symptoms ... mature plasma cells ... TAFRO #diagnosis #management ... #rheumatology #
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