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rheumatology treatment hemophagocytic hlh lymphohistiocytosis chronic cll hemeonc hodgkins lymphocytic lymphoma syndrome adultonset behcet causes classification coagulation comparison dic differential
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Disease Clinical ... Differential Diaqnoses ... Complications: MAS ... #diagnosis #management
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... phenomenon CLL Diagnosis ... cells can indicate disease ... #diagnosis #workup ... #oncology #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... arthritis (sJIA) • Adult-onset ... Fever is the main clinical ... #Syndrome #Diagnosis ... #Management #Hematology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Epidemiology: young adults ... • Clinical features ... involved) • No leukemic ... NonHodgkins #comparison #oncology ... #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
in adults • Disorder ... immunophenotype Clinical ... chemotherapy for low-risk disease ... #oncology #hematology ... #management
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... accumulation of clinical ... : SLE+++, Adult-onset ... Still disease, ... #management #treatment
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... excessive macrophage activation ... age, however the disease ... also observed in adults ... #hematology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Epidemiology: • Young adults ... association • M > F Clinical ... Behcet syndrome (Clinical ... tears, Ischemia, Leukemia ... #management #signs
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Differential Diagnosis ... rheumatoid arthritis, adult-onset ... Chronic B-cell activation ... Hodgkin lymphoma and leukemia
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Recent history of trauma ... promyelocytic leukemia ... organ damage Clinical ... • Severe Liver Disease ... #hematology
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