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rheumatology treatment dermatology syndrome hemophagocytic lymphohistiocytosis activation adultonset arthritis behcet classification coagulation cutaneous dic differential disseminated eschar gangrenosum hodgkins intravascular
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
lymphohistiocytosis (HLH ... arthritis (sJIA) • Adult-onset ... Fever is the main clinical ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... : SLE+++, Adult-onset ... Still disease, ... Drugs, Unknown cause ... #management #treatment
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Disease Clinical ... Differential Diaqnoses ... Complications: MAS ... #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... age, however the disease ... also observed in adults ... #management #treatment ... #hematology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Epidemiology: • Young adults ... common in Asia • HLA-B51 ... association • M > F Clinical ... Behcet syndrome (Clinical ... #management #signs
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
history • Young adults ... Hodgkin Lymphoma - Clinical ... number of sites of disease ... classification #hematology ... #oncology #management
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Arthritis Differential Diagnosis ... Noninflammatory • Trauma ... weeks) Can Be Caused ... arthritis • Adult ... #MSK #rheumatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Recent history of trauma ... organ damage Clinical ... • Severe Liver Disease ... #Coagulation #diagnosis ... #management #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... salivary ducts Clinical ... Nephrogenic DI Hematologic ... phenomenon (16%) MSK ... #Diagnosis #Management
Monkeypox What? Monkeypox virus belongs to the family Poxviridae, subfamily Chordopoxvirinae, and genus orthopoxvirus Viral zoonotic disease that is
Viral zoonotic disease ... that is caused ... both children and adults ... three weeks Clinical ... #Management #Dermatology
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