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differential treatment hematology rheumatology infectiousdiseases oncology causes hemophagocytic hlh lymphohistiocytosis nephrology signs summary algorithm barre blood chronic cord guillain hematuria
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... with no early symptoms ... weeks without infection ... Diagnosis: • ... cells can indicate disease
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Epidemiology: young adults ... e.g., HIV), EBV infection ... • Clinical features ... Etiology: - Infections ... Differential Diagnosis
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Disease Clinical ... : • Infectious ... Complications: MAS ... #diagnosis #management
BEE Syndromes - Non-inflammatory Causes Immune-mediated conditions affecting the Brain, Eye, and Ear Visual or auditory symptoms in
conjunction with symptoms ... • Lyme disease ... nasal squamous cell ... MRI lesions and clinical ... #neurology #noninflammatory
Causes of Peripheral and Central Vertigo PERIPHERAL VERTIGO 1. Benign paroxysmal positional vertigo (BPPV) - Short-lived (typically less
often in older adults ... history of viral infection ... Head trauma - Symptoms ... Syndrome usually ... #differential #diagnosis
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... - Due to Viral infection ... Clinical Presentation ... malignancies -> CLL ... significance (MGUS), CLL
Facial Swelling - Differential Diagnosis Framework for Facial Edema Infectious: • Dental abscess • Ludwig's angina • Vincent's angina • Cellulitis •
- Differential Diagnosis ... Facial Edema Infectious ... polymyositis • Adult-onset ... Still's disease ... - CLL Others
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
arthritis (sJIA) • Adult-onset ... Clinical Presentation ... Fever is the main clinical ... SLE], AOSD) • Infection ... #Diagnosis #Management
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... : SLE+++, Adult-onset ... Still disease, ... #management #treatment
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to impaired B-cell ... to 8 years Clinical ... : • Nephrotic syndrome ... (Epstein-Barr syndrome ... #management
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