29 results
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... arthritis (sJIA) • Adult-onset ... Fever is the main clinical ... Treatment: • Corticosteroids ... #Syndrome #Diagnosis
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Activation of CD8 ... accumulation of clinical ... diseases: SLE+++, Adult-onset ... Drugs, Unknown cause ... Treatment: •
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Disease Clinical ... Complications: MAS ... #management #treatment ... #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... excessive macrophage activation ... also observed in adults ... : HLH signs and ... #hematology
Cardiac Tamponade - Guidelines for Crises in Anaesthesia
Caused by an accumulation of blood, pus, effusion fluid
cardiothoracic surgery, trauma ... • Diagnostic ... thoracotomy is a better treatment ... • Fluid bolus (Adult ... examination and vital signs
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
Risk factors: Critical ... sequestration and activation ... without other cause ... Transfusion #Reactions #hematology ... #diagnosis #comparison
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... Physical Exam/Signs ... phenomenon CLL Diagnosis ... microglobulin Treatment ... workup #oncology #hematology
Oroya Fever
Hematologic disease caused by Bartonella bacilliformis
Restricted to the Andes highlands of Peru & Ecuador
B. bacilliformis:
Oroya Fever Hematologic ... disease caused ... Lutzomyia verrucarum Clinical ... Clinical Presentation ... TREATMENT: ​• Acute
Chagas Disease - American Trypanosomiasis - Diagnosis and Management Summary
Chagas disease (American trypanosomiasis) is an infectious
Trypanosomiasis - Diagnosis ... infectious disease caused ... Romana's sign ... Standard regimen: Adult ... Regimens: • Adult
Peri-operative Hyperthermia - Guidelines for Crises in Anaesthesia
If prolonged or ≥ 39 C this is a
39 C this is a clinical ... Treatment depends ... hyperthermia crisis (late sign ... amphetamines) Toxic: • Radiologic ... Anesthesia #Checklist #Diagnosis