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management rheumatology differential adultonset arthritis hematology hemophagocytic hlh infections lymphohistiocytosis pulmonary summary activation aids bronchiectasis cardiology endocarditis francisella fungal hiv
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's ... Disease (AOSD) ... : High spiking fever ... : high fever, CRP ... #Disease #AOSD
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... triad: Fever, Arthralgia ... Complications: MAS ... #Disease #diagnosis ... #management #treatment
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
arthritis (sJIA) • Adult-onset ... Still disease ... erythematosus [SLE], AOSD ... Treatment: • Corticosteroids ... #Syndrome #Diagnosis
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... mL Gf consider MAS ... Treatment - Mild ... #onset #Stills ... #disease #AOSD #
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
activation of macrophages ... • Clinical: fever ... • Autoimmune diseases ... : SLE+++, Adult-onset ... Still disease,
Septic Arthritis - Diagnosis and Management Summary Clinical Exam: hot, swollen, pain with passive AND active ROM
active ROM +/- fever ... , chills, malaise ... osteomyelitis, trauma ... necrosis, Lyme disease ... Treatment: admission
Tularemia - Diagnosis and Management Summary Francisella tularensis - Aerobic fastidious gram-negative Coccobacillus - Zoonotic Infection •
Ulceroglandular: Fever ... More common in adults ... : • Severe Disease ... #management #treatment ... #infectiousdiseases
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
with excessive macrophage ... age, however the disease ... also observed in adults ... following: • Fever ... • Bicytopenia Treatment
Lung Infections in HIV - Differential Diagnosis Framework Disease by CD4 Count: Any CD4 Count: • Mycobacterium tuberculosis,
- Differential Diagnosis ... Framework Disease ... angioinvasive disease ... function of alveolar macrophages ... #infectiousdiseases
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Arthritis Differential Diagnosis ... Noninflammatory • Trauma ... • Rheumatic fever ... arthritis • Adult ... onset Still's
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