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management rheumatology adultonset hematology hemophagocytic hlh lymphohistiocytosis summary arthritis chagas hemeonc macrophage mas onset septic syndrome trypanosomiasis
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's ... Disease (AOSD) ... #AdultOnset #Stills ... #Disease #AOSD ... #management #treatment
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Differential Diaqnoses ... Complications: MAS ... #Disease #diagnosis ... #management #treatment
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
arthritis (sJIA) • Adult-onset ... Still disease ... erythematosus [SLE], AOSD ... Treatment: • Corticosteroids ... #Syndrome #Diagnosis
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... mL Gf consider MAS ... Treatment - Mild ... #onset #Stills ... #disease #AOSD #
Septic Arthritis - Diagnosis and Management Summary Clinical Exam: hot, swollen, pain with passive AND active ROM
ROM +/- fever, chills ... osteomyelitis, trauma ... necrosis, Lyme disease ... 90% sensitive in pediatrics ... but NOT adults
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... IFN-y) → Excessive activation ... • Autoimmune diseases ... : SLE+++, Adult-onset ... Still disease,
Chagas Disease - American Trypanosomiasis - Diagnosis and Management Summary Chagas disease (American trypanosomiasis) is an infectious
Trypanosomiasis - Diagnosis ... , reactivation in ... Standard regimen: Adult ... Regimens: • Adult ... 90-120 days • Pediatric
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
by uncontrolled activation ... to find in an adult ... - Common in: Adults ... ▪ Autoimmune diseases ... (often termed MAS-HLH
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