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differential hematology activation adultonset ana antinuclear disease erythematosus hemeonc hemophagocytic hlh lupus lymphohistiocytosis macrophage mas patterns sjogrens sle stills systemic
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Complications: MAS ... hepatitis • Pulmonary ... #management #treatment ... #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... (MAS) Classified ... arthritis (sJIA) • Adult-onset ... #Diagnosis #Management ... #Hematology #Rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
33% of healthy adults ... SLE), Sjogren's Syndrome ... , Interstitial Pulmonary ... ANA #patterns #rheumatology ... #diagnosis #differential
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Skin Disease Classification ... Differential Diagnosis ... rheumatoid arthritis, adult-onset ... Non-autoimmune rheumatologic ... #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Diagnosis: • Dry ... Disease: • 10%-15% Pulmonary ... , INC risk PE, Pulmonary ... #Rheumatology # ... Diagnosis #Management
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... • Cogan Syndrome ... C-ANCA) pattern: antibodies ... #rheumatology # ... classification
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
to find in an adult ... - Common in: Adults ... (often termed MAS-HLH ... inhibitors, anti-IFN-γ antibodies ... #Management #Hematology
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