18 results
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Syndrome (MAS) ... arthritis (sJIA) • Adult-onset ... #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Complications: MAS ... hepatitis • Pulmonary ... #management #treatment ... #rheumatology
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Pulmonary Renal ... Renal Syndromes ... or serologies + symptoms ... #Renal #Syndromes ... #management #treatment
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... excessive macrophage activation ... also observed in adults ... HLH signs and symptoms ... #management #treatment
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
- Differential Diagnosis ... Framework and Management ... Rhabdomyolysis: • Trauma ... : • Triad of symptoms ... #Management #causes
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Imaging: CXR- pulmonary ... : >3 symptoms, or ... Anaphylaxis, Acute Renal ... #management #hematology
Adult Onset Still's Disease
Systemic inflammation with urticarial rash.
Rash: 
 • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... the chest/trunk Symptoms ... mL Gf consider MAS ... #rheumatology # ... management
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
and Management ... , and possibly renal ... Pulmonary: dyspnea ... acute sarcoidosis Pulmonary ... #Management #Signs
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Epidemiology: • Young adults ... meningitis), MCC CNS symptoms ... #diagnosis #management ... #signs #symptoms ... #rheumatology #
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
- Differential Diagnosis ... Legionnaires disease • Pulmonary ... 94 and 84% Renal ... Demand ischemia • Trauma ... associated with any symptoms