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management rheumatology hematology hemophagocytic hlh infectiousdiseases lymphohistiocytosis syndrome adultonset cap community disease fusarium gbs guillain hemeonc infections macrophage mas neurology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... the secondary or acquired ... arthritis (sJIA) • Adult-onset ... Treatment: • Corticosteroids ... #Syndrome #Diagnosis
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Disease Clinical ... Complications: MAS ... hepatitis • Pulmonary ... #management #treatment
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... accumulation of clinical ... Assessment • Clinical ... Purtilo (XLP) Acquired ... diseases: SLE+++, Adult-onset
Guillain-Barré Syndrome (GBS) Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness Epidemiology: • Incidence: 1
Meningococcal), surgery, trauma ... transplantation CLINICAL ... and cauda equina TREATMENT ... specific therapy, the clinician ... ventilation is required
Community Acquired Pneumonia (CAP) - Diagnosis and Management Pneumonia Signs/Symptoms: • Confusion/disorientation (LR + 1.9) • Cough
Pneumonia (CAP) - Diagnosis ... be initiated in adults ... with clinically ... #Pulmonary #Community ... #Acquired
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
to find in an adult ... • Secondary (Acquired ... - Common in: Adults ... (often termed MAS-HLH ... Clinical Presentation
Toxocariasis Pathogen: Toxocara - worldwide distributed helminth Transmission: • Dogs and cats are the major source
• Humans acquire ... Adult worms develop ... larva migrans Diagnosis ... • History + clinical ... #microbiology
Fusarium Infections Acquired through: 1. Inhalation of airborne conidia > germinates > blood > disseminated 2. Trauma (implantation with
Fusarium Infections Acquired ... Trauma (implantation ... incubation 4 major clinical ... Refractory FUO, Sino-pulmonary ... disease: • Optimal treatment
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