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management differential rheumatology infections treatment aids hematology hemophagocytic hiv lymphohistiocytosis syndrome activation alkaline alp behcet brain cerebritis chagas erythematosus fungal
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
) Pathophysiology ... salmonella, ...), Parasites ... • Autoimmune diseases ... : SLE+++, Adult-onset ... Still disease,
CNS Ring-Enhancing Lesions - Immunocompromised vs Immunocompetent Multiple Ring-Enhancing Lesions: • Toxoplasmosis (CD4 < 100) • Other
Chorioretinitis • Diagnosis ... • Nocardia • Parasitic ... #differential #diagnosis ... #causes #radiology ... #neurology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
lymphohistiocytosis (HLH ... arthritis (sJIA) • Adult-onset ... nervous system (CNS ... hypersensitivity syndromes • HLH ... Activation #Syndrome #Diagnosis
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Cerebrovascular Disease ... , PRES Pathophysiology ... autoantibodies that will cause ... #neurology #rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Epidemiology: • Young adults ... common in Asia • HLA-B51 ... skin injury) • Neurologic ... basal ganglia, CNS ... meningitis), MCC CNS
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
- Differential Diagnosis ... Demyelinating disease ... caused by the JC ... opportunistic #InfectiousDiseases ... #Neurology
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
Most cases diagnosed ... membrane into the CNS ... Malnutrition • Wilson's disease ... respiratory failure • Neurologic ... Phosphatase: • Other causes
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome caused ... to find in an adult ... ▪ Autoimmune diseases ... (often termed MAS-HLH ... Pathophysiology
Chagas Disease - American Trypanosomiasis - Diagnosis and Management Summary Chagas disease (American trypanosomiasis) is an infectious
Trypanosomiasis - Diagnosis ... caused by the protozoan ... parasite Trypanosoma ... Standard regimen: Adult ... Regimens: • Adult
Hearing Loss - Differential Diagnosis Framework Hearing Loss Types: • Conductive • Sensorineural • Mixed Presbycusis is the most common type
- Differential Diagnosis ... common type in adults ... include a: • Neurologic ... auditory nerve (CN ... cause unknown)
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