5 results
Acromegaly 
Caused by over-secretion of growth hormone (GH) from the pituitary gland. 
The condition is rare
over-secretion of growth hormone ... (GH) from the pituitary ... #Acromegaly #Signs ... #Symptoms #Diagnosis ... #Endocrinology
Clinical Effects of Large and Small Pituitary Tumours
Local complications - Headache, Visual field defect, Disconnection hyperprolactinaemia,
apoplexy) Hormone ... Hypogonadism • Acromegaly ... #Tumors #Signs ... #Symptoms #Diagnosis ... #Endocrinology
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... - Giantism or acromegaly ... #FeedbackLoop #endocrinology ... #pathophysiology ... #pituitary
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
Growth Hormone Excess ... Overproduction #diagnosis ... #signs #symptoms ... #endocrinology ... #pathophysiology
Acromegaly Testing Algorithm
INDICATIONS FOR TESTING:
 • Adults – enlarged facial or acral features, abnormal musculoskeletal growth
Acromegaly Testing ... Algorithm INDICATIONS ... load • Growth Hormone ... #Testing #Algorithm ... #diagnosis #endocrinology