31 results
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Idiosyncratic Drug-induced Liver ... or symptoms of liver ... Drug #induced #Liver ... #Diagnosis #Management
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... - Differential ... Bile Ducts • Common ... • Others #LFTs ... #Hepatology #LiverEnzymes
Common Etiologies of Cirrhosis

Inflammation

 - Hepatitis B (15 percent)

 - Hepatitis C (47 percent)

 - Schistosomiasis
Common Etiologies ... Nonalcoholic fatty liver ... 14 percent) #Diagnosis ... #Differential # ... Hepatology #Cirrhosis
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs ... • Gilbert's syndrome ... #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... presence of metabolic syndrome ... #LFTs #Abnormal ... #Algorithm #Hepatology ... #Differential #
Hypocalcemia - Diagnosis and Management
PTH Independent (↑ PTH)
 • LOW VIT D
    -
Hypocalcemia - Diagnosis ... and Management ... - Activation: Liver ... Iatrogenic (most common ... #differential #
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... hepatocytes → Liver ... malaise) → Acute liver ... Transfer to a liver ... #AFLP #Fatty #Liver
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
Liver Disease in ... necrosis HELLP Syndrome ... Hemolysis, Elevated Liver ... features: Liver ... #diagnosis #icp
Portal Hypertension - Differential Diagnosis
Portal Pressure = the pressure difference between the pressure in the portal
Diagnosis Portal ... >10 mmHg - clinically ... sarcoidosis) • Liver ... metastasis • Fatty liver ... #hepatology
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
disease to acute liver ... arthralgias) are common ... hepatocellular pattern of liver ... Muscle Abs (ASMA) (common ... #Management #Hepatology