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diagnosis algorithm primary transaminitis abnormal alkaline cirrhosis elevation hepatitis management obstetrics pbc phosphatase pregnancy causes chemistry comparison disease enzymes fatty
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... or AST > ALP): ... Wilsons, Pregnancy - AFLP ... #Elevated #Abnormal
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... specific for the liver ... ALP - Biliary ... SinaiBmoreIMRes #Liver ... Transaminitis #diagnosis #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... specificity to elevated ... chemistry #diagnosis #differential ... #Hepatology #transaminitis ... #LFTs #RValue #
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... • Pregnancy - AFLP ... Duct Stone • Biliary ... • Others #LFTs ... #Hepatology #LiverEnzymes
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Alkaline Phosphatase (ALP ... - Increased ALP ... disturbance (obstructed liver ... Highest • Bone • Liver ... Cholangitis (PBC
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... specificity to elevated ... > ALP: Typical ... disease - If ALP ... diagnosis #algorithm #hepatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
cholestasis → Cirrhosis/Liver ... obstruction • ALP ... or higher • Liver ... bile ducts Differential ... diagnosis #workup #hepatology
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Liver Disease in ... Liver enzymes, ... of Pregnancy (AFLP ... features: Liver ... diagnosis #icp #HELLP #AFLP
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... of Pregnancy (AFLP ... hepatocytes → Liver ... iMedEducation #AFLP ... #Fatty #Liver #
Primary Biliary Cirrhosis - Diagnosis Algorithm Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort Signs: Jaundice, Xanthelasmata, Hepatomegaly Associated history:
Primary Biliary ... Elevated ALP 2. ... Liver biopsy findings ... #PBC #Primary #Biliary ... Diagnosis #Algorithm #hepatology
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