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diagnosis liver algorithm transaminitis gastroenterology hepatitis abnormal aclf aflp aih autoimmune causes chemistry chronic cirrhosis dili drug enzymes failure fatty
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... Hepatopathy • Acute ... injury) • Ischemic ... #LFTs #Differential ... #Diagnosis #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Chronic - ongoing ↑ LFTs ... #differential # ... Diagnosis #Management ... gastroenterology #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Injury Transaminase ... > 20x normal - Acute ... #Injury #hepatology ... #LFTs #transaminitis ... #differential #
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... injury < 26 weeks ... chemistry #diagnosis #differential ... #Hepatology #transaminitis ... #LFTs #RValue #
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... Tests of synthetic function ... #differential # ... diagnosis #algorithm #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... ACLF) Clinical Guidelines ... Injury (DILI) ... Failure #Cirrhosis #Hepatology ... gastroenterology #management
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... headache, malaise) → Acute ... infiltration) Differential ... Maternal Support - Critical ... #Pregnancy #hepatology
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... /or suspicious clinical ... #LFTs #Abnormal ... #Algorithm #Hepatology ... #Differential #
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
Hypertension - Differential ... >10 mmHg - clinically ... hepatic synthetic function ... • Cirrhosis/acute ... Diagnosis #causes #hepatology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
subclinical disease to acute ... injury, though ... Hepatitis (eg Viral) Management ... AIH #Diagnosis #Management ... #Hepatology
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