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diagnosis liver gastroenterology transaminitis abnormal aclf acute aflp chemistry chronic cirrhosis drug enzymes fatty hepatitis hepatocellular idiosyncratic induced interpretation obgyn
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Injury (DILI) ... Chronic - ongoing ↑ LFTs ... #differential # ... gastroenterology #algorithm ... gastroenterology #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Clinical Guidelines ... Injury (DILI) ... Hepatitis Procedures Management ... #Hepatology #gastroenterology ... #management #diagnosis
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... Injury → liver ... Injury Differential ... #Injury #Differential ... #LFTs #hepatitis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... Failure (ALF): ... • Liver injury ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
failure rapidly ... → Multiorgan failure ... 10x ULN), ↑Tbili/Dbili ... infiltration) Differential ... #Pregnancy #hepatology
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
tests algorithm ... tests, synthetic failure ... #LFTs #Abnormal ... #Algorithm #Hepatology ... #Differential #
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