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diagnosis liver transaminitis algorithm gastroenterology aclf acute aflp chemistry chronic cirrhosis fatty function hepatitis hepatocellular idiosyncratic induced interpretation obgyn obstetrics
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Liver Injury (DILI ... Chronic - ongoing ↑ LFTs ... #Liver #Injury # ... Idiosyncratic #differential ... gastroenterology #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... (>1000): • DILI ... (Drug-induced liver ... injury) • Ischemic ... Diagnosis #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Clinical Guidelines ... Hepatitis (AAH) Drug-Induced ... Liver Injury (DILI ... #Hepatology #gastroenterology ... #management #diagnosis
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... Injury → liver ... failure 1) Hepatocellular ... Injury Differential ... #Injury #Differential
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... Failure (ALF): ... • Liver injury ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
failure rapidly ... → Multiorgan failure ... 10x ULN), ↑Tbili/Dbili ... infiltration) Differential ... #Pregnancy #hepatology
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