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diagnosis liver algorithm transaminitis gastroenterology hepatitis aclf aih autoimmune causes chemistry chronic cirrhosis dili failure function idiosyncratic induced interpretation rvalue
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Liver Injury (DILI ... Chronic - ongoing ↑ LFTs ... Calculate R-Value • Hepatocellular ... #differential # ... gastroenterology #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver ... Injury - Differential ... Injury → liver ... Liver Injury Differential ... #Liver #Injury
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... Hepatopathy • Acute ... 1000): • DILI (Drug-induced ... liver injury) ... Diagnosis #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Liver Injury - Differential ... Diagnosis Hepatocellular ... , Recreational Drugs ... #Injury #Differential ... #algorithm #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... ALP) • R > 5: Hepatocellular ... chemistry #diagnosis #differential ... #Hepatology #transaminitis ... #LFTs #RValue #
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... ACLF) Clinical Guidelines ... Hepatitis (AAH) Drug-Induced ... Liver Injury (DILI ... Failure #Cirrhosis #Hepatology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
subclinical disease to acute ... - Typically hepatocellular ... injury, though ... AIH #Diagnosis #Management ... #Hepatology
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