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hematology management hemophagocytic hlh lymphohistiocytosis abnormal acidosis agglutinin amyloid amyloidosis atlas beaus causes chronic classification cll cold cvid differential disease
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... with leukopenia, anemia ... function tests ... #Syndrome #Diagnosis ... #Rheumatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral Infection Clinical ... symptoms - most common ... test #cold # ... #hematology #diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... syndrome associated ... excessive macrophage activation ... symptoms can mimic common ... lymph node, or liver
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to 8 years Clinical ... disease • Liver ... autoimmune hemolytic anemia ... : • Nephrotic syndrome ... (Epstein-Barr syndrome
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Epidemiology: • Most common ... adults in the west ... Orange or Hep C Clinical ... • Neutropenia, anemia ... • Richter’s Syndrome
Amyloidosis - Summary Group of disorders associated with extracellular deposition of fibrils formed from low-molecular-weight proteins in
Clinical suspicion ... Amyloidosis Clinical ... : • Nephrotic syndrome ... nephropathy is common ... Inflammation → Macrophage activation
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... lymphopenia, low PLT • Anemia ... Kidney disease common ... Chronic B-cell activation ... #Rheumatology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
- Differential Diagnosis ... The most common ... tests before beginning ... - Compartment syndrome ... 30mmHg) - Severe anemia
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
Acquired) HLH: - Common ... Clinical Presentation ... • Common Signs ... - Cytopenias (anemia ... - Elevated liver
Nail Pathologies - Findings in or Near Nails Paronychia A superficial infection of the proximal and lateral
the Fingers Clinically ... include diabetes, anemia ... seen in Reiter's syndrome ... Abnormal #Pathology #Diagnosis ... #Clinical #Signs
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