7 results
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
for Hemolysis - ... thrombocytopenic purpura ... , CLL, lymphoma, ... #Hemolytic #Intravascular ... #hematology #anemia
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
purple, hemorrhagic skin ... DIC/TTP/HUS - Hemolytic ... anemia - Splenomegaly ... #hematology #rheumatology ... #nonpalpable #dermatology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Lupus (SLE) General ... Sjögrens (15%) Skin ... , Purpura, Urticaria ... #SLE #systemic ... #rheumatology
Causes of Purpura or Easy Bruising in Children

Platelet count reduced, i.e. thrombocytopenia
 - Increased platelet destruction
(systemic lupus ... Congenital heart disease ... #Purpura #Bruising ... #Causes #peds #pediatrics ... #diagnosis #differential
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Systemic lupus ... [SLE], AOSD) • ... #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• Coombs (-) hemolytic ... anemia due to cold ... Paraproteinemias #Hematology ... #Differential #Diagnosis ... #Oncology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... lymphopenia, low PLT • Anemia ... Chronic B-cell activation ... #Systemic #Lupus ... #Rheumatology