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differential hematology causes algorithm management erythematosus leukemia pruritus secondary signs sle symptoms activation behcet bruising classification cll common cvid extravascular
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... thrombocytopenic purpura ... usually IgG) (e.g. lupus ... , CLL, lymphoma, ... #hematology #anemia
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Sjögrens (15%) Skin ... Butterfly rash, Vasculitis ... , Purpura, Urticaria ... ) Blood (75%): Anemia ... #rheumatology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
purple, hemorrhagic skin ... DIC/TTP/HUS - Hemolytic ... anemia - Splenomegaly ... #hematology #rheumatology ... #nonpalpable #dermatology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... • Leukemia • Lymphoma ... : • Systemic lupus ... #Hematology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Pruritus - Generalized ... Creatinine & BUN: • Chronic ... Differential: • Lymphoma ... Myelodisplastic syndrome ... #generalized #dermatology
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Dermatomyositis Erythema chronicum ... lesions • Discoid lupus ... Sarcoidosis #dermatology ... #differential #diagnosis ... #rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Coombs (-) hemolytic ... anemia due to cold ... Paraproteinemias #Hematology ... #Differential #Diagnosis ... #Oncology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... Eosinophilia, asthma, chronic ... inflammation Others: • Lupus ... as systemic lupus ... #rheumatology #
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... , deficiency anemia ... , Vasculitides, ... IBD, Celiac disease ... #Algorithm #hematology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Pruritus - No Primary Skin ... Creatinine & BUN: • Chronic ... Differential: • Lymphoma ... Myelodisplastic syndrome ... #generalized #dermatology
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