223 results
Causes of Hypernatremia - Differential Diagnosis
Inadequate water intake:
 • Lack of access to water
Extrarenal hypotonic fluid
perspiration Renal ... Diuretics • Osmotic ... Diagnosis #Causes #nephrology
Causes of Generalized Edema - Differential Diagnosis Algorithm
Overfill (Increased renal sodium retention, Urine Na > 40meq/L)
Overfill (Increased renal ... Increased Interstitial Oncotic ... Decreased Capillary Oncotic
Intra-renal urea recycling to maintain the medullary osmotic gradient

Dr. Muner Mohamed @MunerMohamed1

#urea #recycling #osmotic #gradient #pathophysiology
Intra-renal urea ... the medullary osmotic ... urea #recycling #osmotic ... pathophysiology #nephrology
Causes of Hyponatremia - Differential Diagnosis Algorithm
Hypovolemia, UNa > 20: 
 • Renal losses, Diuretic excess,
UNa > 20: • Renal ... Bicarbonaturia with renal ... alkalosis, Ketonuria, Osmotic ... Acute or chronic renal ... Algorithm #Causes #nephrology
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
canagliflozin 2) Osmotic ... Sites #Action #nephrology
Hormones Acting on the Nephron - Diuretics and Their Site of Action
 1) Acetazolamide
 2) Osmotic
Acetazolamide 2) Osmotic ... Pathophysiology #Nephrology
Drug Induced Kidney Injury
 • Pre-Renal: NSAIDS, CNI, ACEI/ARB, IL-2 therapy, Diuretics CAR-T therapy
 • Osmotic
Injury • Pre-Renal ... CAR-T therapy • Osmotic ... diagnosis #algorithm #nephrology
Diuretics sites of action on the nephron
1) Acetazolamide (carbonic anhydrase inhibitor)
2) Osmotic diuretics (e.g. mannitol)
3) Loop
inhibitor) 2) Osmotic ... #pharmacology #nephrology
Hypokalemia Differential Diagnosis Algorithm

Low intake 
• poor oral intake 

Renal loss 
• Medication 
• Hypomagnesemia 
•
oral intake Renal ... Hypomagnesemia • Osmotic ... Nonreabsorbable anions • Renal
Hypernatremia - Differential Diagnosis Workup Algorithm

1) Check Urine Osmolality:
 > 600 mOsm/kg - Implies extrarenal mechanism
mOsm/kg - Implies renal ... , Ingestion Renal ... Hypovolemic: Diuretics, osmotic ... Workup #Algorithm #nephrology