304 results
Causes of Generalized Edema - Differential Diagnosis Algorithm
Overfill (Increased renal sodium retention, Urine Na > 40meq/L)
• Nephrotic Syndrome ... Increased Interstitial Oncotic ... Decreased Capillary Oncotic ... • Nephrotic syndrome ... Respiratory Distress Syndrome
Irritable Bowel Syndrome (IBS) Treatment Algorithm

IBS-Constipation:
 • Constipation: Osmotic laxatives
 • Abdominal pain: Antispasmodics

IBS-Diarrhea:
 • Diarrhea:
Irritable Bowel Syndrome ... Constipation: Osmotic ... Irritable #Bowel #Syndrome
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
canagliflozin 2) Osmotic ... Sites #Action #nephrology
Hormones Acting on the Nephron - Diuretics and Their Site of Action
 1) Acetazolamide
 2) Osmotic
Acetazolamide 2) Osmotic ... Pathophysiology #Nephrology
Causes of Hyponatremia - Differential Diagnosis Algorithm
Hypovolemia, UNa > 20: 
 • Renal losses, Diuretic excess,
alkalosis, Ketonuria, Osmotic ... Cerebral salt wasting syndrome ... Stress, Drugs, Syndrome ... • Nephrotic syndrome ... Algorithm #Causes #nephrology
Diuretics sites of action on the nephron
1) Acetazolamide (carbonic anhydrase inhibitor)
2) Osmotic diuretics (e.g. mannitol)
3) Loop
inhibitor) 2) Osmotic ... #pharmacology #nephrology
Causes of Hypernatremia - Differential Diagnosis
Inadequate water intake:
 • Lack of access to water
Extrarenal hypotonic fluid
Diuretics • Osmotic ... Diagnosis #Causes #nephrology
Hyponatremia Correction
1. Indications for Hypertonic Saline: seizure, coma, focal findings
   - typically occurs with
Hyponatremia → Osmotic ... Demyelination Syndrome ... rate #management #nephrology
Workup for Hypophosphatemia - Differential Diagnosis Framework
Rule out spurious hypophosphatemia: paraproteinemia, acute leukemia
Measure Urine Fractional Excretion
alkalosis, Hungry bone syndrome ... Tumor genesis syndrome ... FGF-23: Fanconi syndrome ... , CA Inh., Osmotic ... Workup #phosphate #nephrology
Hypernatremia - Differential Diagnosis Workup Algorithm

1) Check Urine Osmolality:
 > 600 mOsm/kg - Implies extrarenal mechanism
Hypovolemic: Diuretics, osmotic ... Hypervolemic: Conn syndrome ... , Cushing syndrome ... Workup #Algorithm #nephrology