27 results
Hormones Acting on the Nephron - Diuretics and Their Site of Action
 1) Acetazolamide
 2) Osmotic
Hormones Acting ... Their Site of Action ... Acetazolamide 2) Osmotic ... Pathophysiology #Nephrology
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Diuretic Sites of Action ... canagliflozin 2) Osmotic ... Diuretics #Sites #Action ... #nephrology #pharmacology
Diuretics sites of action on the nephron
1) Acetazolamide (carbonic anhydrase inhibitor)
2) Osmotic diuretics (e.g. mannitol)
3) Loop
Diuretics sites of action ... inhibitor) 2) Osmotic ... #pharmacology #nephrology ... medications #sites #action
Irritable Bowel Syndrome (IBS) Treatment Algorithm

IBS-Constipation:
 • Constipation: Osmotic laxatives
 • Abdominal pain: Antispasmodics

IBS-Diarrhea:
 • Diarrhea:
Irritable Bowel Syndrome ... (IBS) Treatment ... Constipation: Osmotic ... Irritable #Bowel #Syndrome ... #IBS #Treatment
Summary of Diuretic Agents 
Subclass, Drug, Mechanism of Action, Effects, Clinical Applications, Pharmacokinetics, Toxicities, Interaction
CARBONIC ANHYDRASE
, Mechanism of Action ... • Triamterene OSMOTIC ... summary #table #nephrology
Causes of Hyponatremia - Differential Diagnosis Algorithm
Hypovolemia, UNa > 20: 
 • Renal losses, Diuretic excess,
alkalosis, Ketonuria, Osmotic ... Cerebral salt wasting syndrome ... Stress, Drugs, Syndrome ... • Nephrotic syndrome ... Algorithm #Causes #nephrology
Pharmacological Treatment of Hepatorenal Syndrome (HRS)

Midodrine - Alpha agonist incr blood pressure incr renal perfusion pressure
Pharmacological Treatment ... of Hepatorenal Syndrome ... Octreotide - Long-acting ... #HepatoRenal #Syndrome ... #Nephrology #Management
Hyponatremia Correction
1. Indications for Hypertonic Saline: seizure, coma, focal findings
   - typically occurs with
Hyponatremia → Osmotic ... Demyelination Syndrome ... rate #management #nephrology
Hypernatremia - Differential Diagnosis Workup Algorithm

1) Check Urine Osmolality:
 > 600 mOsm/kg - Implies extrarenal mechanism
Hypovolemic: Diuretics, osmotic ... Hypervolemic: Conn syndrome ... , Cushing syndrome ... Workup #Algorithm #nephrology
Workup for Hypophosphatemia - Differential Diagnosis Framework
Rule out spurious hypophosphatemia: paraproteinemia, acute leukemia
Measure Urine Fractional Excretion
alkalosis, Hungry bone syndrome ... Tumor genesis syndrome ... FGF-23: Fanconi syndrome ... , CA Inh., Osmotic ... Workup #phosphate #nephrology