17 results
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... : • Common: fever ... Renal Failure Treatment ... #management #hematology
Disseminated Gonococcal Infection - Diagnosis and Management Summary

Bacteremic spread of the Gram-negative diplococci Neisseria gonorrhoeae. History
Diagnosis and Management ... the preferred test ... typically part of the workup ... : • Fever, chills ... afebrile • Acute
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
- 80% have fever ... - ACS, AKI, acute ... lab signs of end organ ... TLS #diagnosis #management ... #hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
adults in the west ... Lymphadenopathy • Fevers ... microglobulin Treatment ... ’s lymphoma or acute ... Leukemia #diagnosis #workup
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
- Nonremitting fever ... Liver function tests ... Treatment: • Corticosteroids ... #Diagnosis #Management ... #Hematology #Rheumatology
Peri-operative Hyperthermia - Guidelines for Crises in Anaesthesia
If prolonged or ≥ 39 C this is a
emergency: permanent organ ... Treatment depends ... Actively maintained fever ... Checklist #Diagnosis #Management ... #Workup
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... presents as an acute ... following: • Fever ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
IgG4-Related Disease
Clinical history:  Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
 •
specific laboratory tests ... hypergammaglobulinemia, ↑ acute ... Disease #diagnosis #management ... #phenotypes #workup ... #treatment #rheumatology
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
Definition: 
 • Severe adverse drug reaction, characterized by
Fever >38.5 2. ... • SJS/TEN • Acute ... Exanthematous Pustulosis Management ... disease: symptomatic treatment ... SinaiBmoreIMRes #DRESS #Syndrome
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... agents given to organ ... factor (GCSF) treatments ... Workup: • Complete ... #diagnosis #hematology