20 results
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
for workup, including ... Rebound effect from treatment ... Inflammatory Conditions: Rheumatologic ... Vasculitides, IBD, Celiac disease ... Kawasaki, Nephrotic syndrome
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
• Periodic fever ... - Nonremitting fever ... Liver function tests ... Treatment: • Corticosteroids ... #Rheumatology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
- 80% have fever ... - ACS, AKI, acute ... lab signs of end organ ... damage • Treatment ... diagnosis #management #hematology
Acute Retroviral Syndrome
Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection

 •
Syndrome Acute ... Retroviral Syndrome ... Headache (45%) • Fever ... ) Treatment: ... ART to slow HIV disease
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Lymphadenopathy • Fevers ... cells can indicate disease ... microglobulin Treatment ... ’s lymphoma or acute ... Leukemia #diagnosis #workup
IgG4-Related Disease
Clinical history:  Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
 •
IgG4-Related Disease ... specific laboratory tests ... hypergammaglobulinemia, ↑ acute ... management #phenotypes #workup ... #treatment #rheumatology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... : • Common: fever ... Renal Failure Treatment ... unless severe APLS, organ
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
Definition: 
 • Severe adverse drug reaction, characterized by
Fever >38.5 2. ... • SJS/TEN • Acute ... : symptomatic treatment ... • Severe disease ... SinaiBmoreIMRes #DRESS #Syndrome
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... age, however the disease ... presents as an acute ... following: • Fever ... #hematology
Approach to Joint Pain

History:
Is the pain from:
	• Joint
	• Adjacent bursa
	• Tendon
	• Ligament
	• Bone
	• Muscle
	• Referred from
from a visceral organ ... Symptoms of Joint Disease ... Arthritis: • Acute ... Joint #Pain #MSK #rheumatology ... #approach #workup