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diagnosis hematology management leukemia chronic cll differentiation emergencies hemeonc leukostasis lymphocytic oncologic uricacid
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Lysis Syndrome ... - 80% have fever ... - ACS, AKI, acute ... Lysis Syndrome: ... #Lysis #Syndrome
Tumor Lysis Syndrome An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... An acute, life-threatening ... (both ALL and AML ... #Lysis #Syndrome ... #TLS #oncology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... : • Common: fever ... Renal Failure Treatment ... #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, APML, CLL Acute ... smear: Blasts APML ... Fibrinolysis & DIC • Tumor ... lysis syndrome: ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphadenopathy • Fevers ... microglobulin Treatment ... ’s lymphoma or acute ... Leukemia #diagnosis #workup ... #oncology #hematology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
full infectious work-up ... days → add fungal work-up ... antibiotics TLS ... (tumor-lysis syndrome ... low Ca - q8 h TLS
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