17 results
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
for workup, including ... hemolysis, deficiency anemia ... Rebound effect from treatment ... Inflammatory Conditions: Rheumatologic ... Kawasaki, Nephrotic syndrome
Diagnosing Brucellosis
Epidemiological Exposures
- Endemic Regions
- Clinical Micro Lab Technicians
- Animal/Vaccine Exposure: Vets, Slaughterhouse workers, hunters
- Unpasteurized
Constitutional: Fevers ... Weight loss - End Organ ... Tests: - CBC ... + Chemistry: Anemia ... #Criteria #Workup
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Presentation: • Fever ... recurrent infections/fevers ... Treatment: ... #oncology #hematology ... #diagnosis #management
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
with leukopenia, anemia ... Liver function tests ... Treatment: • Corticosteroids ... #Diagnosis #Management ... #Hematology #Rheumatology
Renal Cell Carcinoma (RCC) - Diagnosis and Management Summary
Clinical features - Classic triad (flank pain, hematuria,
Carcinoma (RCC) - Diagnosis ... Anemia (common) ... night sweats, fever ... Budd Chiari syndrome ... disease Imaging and Treatment
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Lymphadenopathy • Fevers ... • Neutropenia, anemia ... microglobulin Treatment ... #workup #oncology ... #hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... agents given to organ ... factor (GCSF) treatments ... Workup: • Complete ... #diagnosis #hematology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
- 80% have fever ... lab signs of end organ ... damage • Treatment ... #TLS #diagnosis ... #management #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Symptoms: High fevers ... Test: Donath-Landsteiner ... test #cold # ... #hematology #diagnosis
Lactic Acidosis - Differential Diagnosis Framework

Type A: Impaired O2 Delivery (DO2)
 • Decreased O2 Delivery: Hypotension
Shock, Severe Anemia ... Ischemia, Compartment Syndrome ... Pain / Exercise, Fever ... Beta-Agonists, ↑ work ... Excerpted from original