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diagnosis hematology management oncology acute agglutinin anemia apml causes chronic classification cold differential differentiation disease hemolytic hemophagocytic hiv hlh hodgkins
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis • Infection: Extrapulmonary tuberculosis, Abscess, Endocarditis,
of Unknown Origin ... Lemierre's syndrome ... malignancies: Lymphoma ... tumors: Renal cell ... #Unknown #Origin
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
adults in the west ... Lymphadenopathy • Fevers ... infiltrate any organ ... microglobulin Treatment ... Leukemia #diagnosis #workup
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
accounts for 10% of all ... • Dyspnea • Fever ... Workup: • Full ... check for other organ ... Treatment • Early
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... - Monoclonal - Lymphoid ... Symptoms: High fevers ... • Diagnostic Test ... Donath-Landsteiner test
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... agents given to organ ... factor (GCSF) treatments ... Workup: • Complete ... #diagnosis #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... • Induce blast cell ... Subacute-Acute: • Common: fever ... Renal Failure Treatment
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
Acute Retroviral Syndrome ... tissues, seeds the lymphoid ... Headache (45%) • Fever ... Labs: • CD4+ T-cell ... ) Treatment:
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... with multiple organ ... following: • Fever ... Low or absent NK cell ... #hematology
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
- Anasarca - Fever ... disease, severe fever ... large B cell lymphoma ... Hypoalbuminemia Treatment ... diagnosis #management #rheumatology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
Nonspecific symptoms: Fever ... Viral infection • Lymphoma ... Diagnosis: • Clinical tests ... affected tissue Treatment ... Polychondritis #rheumatology
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