24 results
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
SLE], AOSD) • Infection ... Liver function tests ... Treatment: • Corticosteroids ... #Management #Hematology ... #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Activation of CD8 ... IFN-y) → Excessive activation ... • Clinical: fever ... Lymphohistiocytosis #diagnosis #management ... #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... excessive macrophage activation ... following: • Fever ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
Disseminated Gonococcal Infection - Diagnosis and Management Summary

Bacteremic spread of the Gram-negative diplococci Neisseria gonorrhoeae. History
Diagnosis and Management ... the preferred test ... typically part of the workup ... • Test all patients ... : • Fever, chills
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
Active TB: • Fever ... Tuberculin skin test ... Tuberculosis Treatment ... TB #Diagnosis #Management ... #Treatment #ActiveTB
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
Active TB: • Fever ... Tuberculin skin test ... Tuberculosis Treatment ... TB #Diagnosis #Management ... #Treatment #ActiveTB
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
- 80% have fever ... lab signs of end organ ... damage • Treatment ... TLS #diagnosis #management ... #hematology
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook

Presentation: 
 • Plts ↓50% (nadir
skin necrosis (at injection ... complex → plt activation ... approach for post-test ... : Confirmatory test ... #Treatment #Hematology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Subacute-Acute: • Common: fever ... Differential Diagnosis: Infection ... APML #diagnosis #management
Peri-operative Hyperthermia - Guidelines for Crises in Anaesthesia
If prolonged or ≥ 39 C this is a
emergency: permanent organ ... Treatment depends ... Actively maintained fever ... Checklist #Diagnosis #Management ... #Workup