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diagnosis management hematology oncology activation apml chronic classification cll differentiation disseminated fungal gonococcal gonorrhea hemophagocytic hlh hodgkins infection leukemia lymphocytic
Disseminated Gonococcal Infection - Diagnosis and Management Summary Bacteremic spread of the Gram-negative diplococci Neisseria gonorrhoeae. History
the preferred test ... typically part of the workup ... • Test all patients ... : • Fever, chills ... #Microbiology #InfectiousDiseases
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
- Nonremitting fever ... SLE], AOSD) • Infection ... Liver function tests ... Treatment: • Corticosteroids ... #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... with multiple organ ... following: • Fever ... : • Infection ... #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
adults in the west ... Lymphadenopathy • Fevers ... weeks without infection ... microglobulin Treatment ... Leukemia #diagnosis #workup
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Subacute-Acute: • Common: fever ... Differential Diagnosis: Infection ... Renal Failure Treatment
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... petechiae) • Frequent infections ... • Parvovirus infection ... agents given to organ ... Workup: • Complete
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
History of EBV infection ... • Dyspnea • Fever ... Hodgkin Lymphoma Workup ... check for other organ ... Hodgkin Lymphoma Treatment
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
respiratory symptoms • Fever ... pulmonary symptoms • Rheumatologic ... • Cough, fever ... cirrhosis, or organ ... ) #Mycoses #InfectiousDiseases
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
Nonspecific symptoms: Fever ... Behcet disease • Infections ... Diagnosis: • Clinical tests ... affected tissue Treatment ... Polychondritis #rheumatology
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