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Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Differential ... and branches • GCA ... lesions-interstitial keratitis, uveitis ... Presentation - Systemic Symptoms ... purpura: strong sign
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... purpura: Strong sign ... Elevated ESR and CRP GCA ... develop in pts with GCA ... • Progressive symptoms
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
and ophthalmic complications ... systemic sx + signs ... very remarkable w/differential ... Treatment of GCA ... #Temporal #Signs
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Eye involvement (uveitis ... Behcet disease) Differential ... Arthritis, AS Treatment ... inhibitors • Uveitis ... diagnosis #management #signs
Psoriatic Arthritis: Complications

 • Ocular - Inflammation of middle layer of the eye (the uvea, which
Ocular - ... choroid layer) -> Uveitis ... - anterior (iritis ... pathophysiology #diagnosis #signs ... #symptoms #Complications
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Autoimmune ANCA vasculitis ... disease: scleritis, uveitis ... palpable purpura 2/2 vasculitis ... or serologies + symptoms ... diagnosis #management #treatment
Hyperthyroidism Overview

Clinical Manifestation of Hyperthyroidism:
 • Fatigue
 • Weight loss
 • Heat intolerance
 • Depression, nervousness
Hyperdefecation • Anterior ... ↑ AST/ALT • Treatment ... causes #diagnosis #differential ... endocrinology #signs ... #symptoms #thyroid
Ankylosing Spondylitis: Extra-articular Manifestations
 • Ocular - Inflammation of the iris, the anterior part of the
Manifestations • Ocular ... • Uveitis - ... Manifestations #Complications ... pathophysiology #diagnosis #signs ... #symptoms
Relapsing Polychondritis

What is it?
Recurrent inflammation of the cartilage in the body (Autoimmune disorder)

Who?
• Most frequently: 40
chondritis • Ocular ... conjunctivitis, keratitis, uveitis ... Polyarteritis Nodosa, GCA ... Multiple myeloma Complications ... affected tissue Treatment