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diagnosis management fungal infections candida algorithm antifungal aspergillus auris betadglucan candidemia candidiasis celiac cglabrata dermatitis disease falsepositives fever fungemia fuo
Invasive fungal infections: Morphology, Risk Factors, Disease Characteristics, Diagnostic Tools, First-Line Treatment Aspergillus, Mucorales, P. Jiroveci, Cryptococcus,
Invasive fungal ... Tools, First-Line Treatment ... , Coccidiodes, Fusarium ... #Invasive #Fungal ... #Infections #InfectousDiseases
Invasive Aspergillus (IA) - Diagnosis and Management Aspergillus is ubiquitous in nature. Most invasive infections are caused
Diagnosis and Testing ... neutropenia (performs best ... positive with Histo, Fusarium ... this morphology Treatment ... #fungal #infectiousdiseases
Invasive Candidiasis (IC) Diagnosis: Culture: • Gold standard, but Slow (~2-3 days), 50% sensitivity • Blood Sample •
Invasive Candidiasis ... Non-culture-based tests ... • Molecular Tests ... susceptibility testing ... Line Targeted Treatment
Fusarium Treatment • Antifungal "susceptibility" can vary with Fusarium spp • F. oxysporum: low MICS to
Fusarium Treatment ... can vary with Fusarium ... moderate Tx in setting ... @ID_fellows #Fusarium ... #Infections #infectiousdiseases
Fusarium Infections Acquired through: 1. Inhalation of airborne conidia > germinates > blood > disseminated 2. Trauma (implantation with
Fusarium Infections ... material) > local invasion ... disease: • Optimal treatment ... moderate Tx in setting ... #Infections #infectiousdiseases
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
Galactomannan Testing ... Other +s: Fusarium ... the use of this test ... colonization vs invasive ... Galactomannan #Fungal #Testing
Hepatopulmonary Syndrome - Diagnosis and Management Summary A defect in arterial oxygenation due to a gas exchange
IPVDs Diagnostic Testing ... oximetry - Non-invasive ... 10 minutes of rest ... ) on room air Treatment ... diagnosis #management #treatment
Fever of Unknown Origin (FUO) Diagnostic Algorithm STEP 1 Perform a comprehensive history and complete physical examination. STEP
Apply appropriate invasive ... tuberculosis skin test ... positive first-tier testing ... diagnostic testing ... Diagnosis #Algorithm #infectiousdiseases
Candida Glabrata Species of Candida Most Commonly Isolated in Bloodstream Infections • Symptomatic mucosal infection is detected
is common with invasive ... Treatment: • Exhibits ... candidemias or invasive ... susceptibility testing ... fungemia #management #infectiousdiseases
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
Histoplasmosis Treatment ... Urinary antigen testing ... Ampho resistant) Invasive ... of 30% to 40% Invasive ... ) #Mycoses #InfectiousDiseases
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