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diagnosis differential hepatology liver management causes lfts rheumatology transaminitis acute gastroenterology arthritis druginduced lupus sle aclf aih aki alcoholic anemia
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Diagnosis Algorithm ... e.g. ascites), Chronic ... hepatitis fibrosis ... #Diagnosis #Algorithm ... #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Drug-induced Liver Injury ... dose dependent injury ... presentation • Chronic ... gastroenterology #algorithm ... gastroenterology #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Cirrhosis • Chronic ... Viral Hepatitis ... • Acute Viral Hepatitis ... (>1000): • DILI ... Drug-induced liver injury
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Drug-Induced Liver Injury ... (DILI) Viral Hepatitis ... #ACLF #Acute #Chronic ... Failure #Cirrhosis #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... • Iatrogenic: DILI ... > 2 • NASH, Chronic ... : > 3 • Chronic ... #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver Injury ... , Toxic Hepatitis ... 5-10x normal - Chronic ... Patterns #Liver #Injury ... #hepatology #LFTs
Non-ACS Myocardial Injury - Elevated Troponin Differential Diagnosis and Workup Algorithm • Chronic Myocardial Injury: End
Diagnosis and Workup ... Algorithm • ... Chronic Myocardial ... (ie Sarcoid), Chronic ... Differential #Diagnosis #Algorithm
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Check Acute viral hepatitis ... > 2 • NASH, Chronic ... viral hepatitis ... : > 3 • Chronic ... #differential #Hepatology
Anemia - Underproduction Diagnostic Algorithm - Iron deficiency anemia - Anemia of chronic inflammation - Anemia
Underproduction Diagnostic Algorithm ... - Anemia of chronic ... - Anemia of chronic ... #hematology #diagnosis ... #differential #workup
Chronic Hepatitis B - Diagnosis and Management Algorithm • Who to treat: Essentially treat the pts with
Chronic Hepatitis ... and Management Algorithm ... Chronic Hepatitis ... #Algorithm #Diagnosis ... Management #Treatment #Hepatology
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