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diagnosis management erythematosus lupus systemic treatment activation cerebritis classification cns eularacr hemophagocytic hlh lymphohistiocytosis macrophage mas neurology summary syndrome
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Erythematosus Clinical ... Delirium, Psychosis, Seizure ... pericarditis • Hematologic ... #SLE #Systemic ... Erythematosus #diagnosis #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... ) Clinical Manifestations ... Movement disorders, Seizure ... Disease, PRES Pathophysiology ... CNS #neurology #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... accumulation of clinical ... >2400 Ul/ml, ↑ LDH ... Autoimmune diseases: SLE ... treatment #summary #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
erythematosus [SLE ... 10,000 ng/mL • Hyponatremia ... Histopathologic criteria ... Diagnosis #Management #Hematology ... #Rheumatology
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