14 results
Hyponatremia (<135 mEq/L) is a common electrolyte abnormality caused by an excess of total body water
Hyponatremia (<135 ... asymptomatic to seizures ... True hyponatremia ... #hyponatremia #ADH ... #Hypovolemia #EBV
Hyponatremia Differential Diagnosis Algorithm - Utilizing Uric Acid 
ADH promotes Urea/uric acid excretion along with water
Hyponatremia Differential ... Utilizing Uric Acid ADH ... retention 1) Serum Osmolarity ... 2) Urine Osmolarity ... 3) Urine Sodium
Hyponatremia - Diagnosis and Treatment
Hyponatremia is usually caused by the inability to excrete water normally.
majority of cases, ADH ... 2) Is ADH elevated ... volume status (EABV ... of symptomatic (seizures ... management #nephrology #sodium
Hyponatremia Diagnostic Algorithm
1) Check serum osmolality
2) Check urine osmolality
3) ADH Dependent - Check volume status, urine
Hyponatremia Diagnostic ... 1) Check serum osmolality ... 2) Check urine osmolality ... 3) ADH Dependent ... status, urine sodium
Cerebral Salt Wasting vs SIADH - Pathophysiology 
1) Neurological event
2) Sodium loss from tubules
3) Naturiesis →
Wasting vs SIADH - Pathophysiology ... Neurological event 2) Sodium ... Hypovolaemia → ADH ... SaltWasting #SIADH #Pathophysiology ... diagnosis #nephrology #hyponatremia
Management of SIADH
Treat underlying cause:
 • Causes can include pain, primary lung pathology, post-operative phenomenon, medications,
promoting passive sodium ... Saline: • If Urine osmolality ... antagonists: • Blocks ADH ... SIADH #Management #hyponatremia
Intracranial Hemorrhage (ICH) and Increased Intracranial Pressure (ICP) - Pathophysiology
ICH Management:
1. Manage Blood Pressure
  •
Pressure (ICP) - Pathophysiology ... Manage ICP and Seizures ... CO2 = dilated BV ... agents = increase osmolarity ... Pressure #ICP #Pathophysiology
SIADH Treatment Options
1. Treat underlying cause of SIADH: Pain, Primary lung pathology, Post-operative phenomenon, Medications, Basically
promoting passive sodium ... NS • If Urine osmolality ... vaptans) • Blocks ADH ... SIADH #Management #hyponatremia
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... accumulation of clinical ... Assessment • Clinical ... >2400 Ul/ml, ↑ LDH ... biologics (CMV +++, EBV
Heat Illnesses and Heat Stroke - Differential Diagnosis Framework

Heat Cramps:
 • Muscle pain or spasm -
Dehydration - Loss of sodium ... heat illness → Hypernatremia ... Collapse: • Pathophysiology ... consciousness, Coma/seizure