10 results
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... with thiazide diuretic ... Rhabdomyolysis Treatment ... #Syndrome #diagnosis ... #nephrology #management
Gitelman Syndrome - Management
Treatment includes
 - Electrolyte replacement - K & Mg, preferably Cl salts
Gitelman Syndrome ... - Management Treatment ... - K & Mg rich food ... In persistent hypokalemia ... #Syndrome #Management
Causes of Hypokalemia
Transcellular Shifts:
 - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
plasma insulin (treatment ... of diabetic ketoacidosis ... use), Gitelman's ... syndrome (mimics ... #differential #diagnosis
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Imaging: CXR- pulmonary ... #APML #diagnosis ... #management #hematology
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
disequilibrium syndrome ... • Diagnosis of ... irrigation • Management ... Torsemide) • Acute pulmonary ... Tolvaptan) • Treatment
It is important to recognize Acute Decompensated Heart Failure (ADHF) as more than just simply a
with presence of pulmonary ... & Dry) is the treatment ... patient causing hypovolemia ... acute coronary syndrome ... #algorithm #management
Clarkson’s Disease - Capillary leak syndrome
Epidemiology: Roughly 150 published cases, Median age 50 years, No sex
Capillary leak syndrome ... Hypovolemia: Asthenia ... edema, compartment syndrome ... filling +++ (risk of pulmonary ... #diagnosis #management
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS

What Is IRIS?
	• A state of hyperinflammatory response that
Reconstitution Inflammatory Syndrome ... Lymphadenitis, pulmonary ... leukoencephalopathy (PML ... #Inflammatory #Syndrome ... #Management
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
before beginning treatment ... - Shock - Hypovolemia ... output - Acute pulmonary ... - Compartment syndrome ... • Type B1: - Diabetes
Myelodysplastic syndromes current treatment algorithm 2018.

From Blood Cancer Journal, Published 24 May 2018

Myelodysplastic syndromes (MDS) are
Myelodysplastic syndromes ... current treatment ... median age at diagnosis ... cardiovascular or pulmonary ... approved by the Food