694 results
Systemic Sclerosis Associated Autoantibodies
Anti-topoisomerase I (anti-Sc170): Diffuse skin disease, Pulmonary fibrosis
Anti-centromere: Limited skin disease (~93-95%), Pulmonary
fibrosis Anti-PM-Sc1: Overlap ... Americans and males, Overlap ... Autoantibodies #diagnosis #rheumatology
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
biliary cholangitis) overlap ... acro-osteolysis, myositis overlap ... Scleroderma #SSc #rheumatology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
sclerosis/polymyositis overlap ... Summary #diagnosis #rheumatology
Vasculitis - Break down based on vessel size 
Distribution of vessel involvement by large vessel vasculitis,
is substantial overlap ... #Diagnosis #Rheumatology
Idiopathic Inflammatory Myopathies (IIM's)

RASH + MUSCLE WEAKNESS → Consider idiopathic inflammatory myopathies (IIM's)

 • Overlap Myositis
(IIM's) • Overlap ... IIMs #diagnosis #rheumatology
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
with SLE-SSc-AlM overlap ... erythematosus #diagnosis #rheumatology
Scleroderma Renal Crisis (SRC)

Clinical Presentation of Scleroderma Renal Crisis:
1) Acute kidney injury
2) Abrupt onset of hypertension
3)
consider PLEX (overlap ... Renal #Crisis #rheumatology
Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Erythematosus #SLE #hematology ... #rheumatology #
Stevens-Johnson syndrome (SJS), Toxic epidermal necrolysis (TEN) and Overlap

 SJS-TEN overlap and TEN - Surface Epidermal
necrolysis (TEN) and Overlap ... SJS-TEN overlap
First-line therapies for Asthma, Asthma-COPD Overlap and COPD

The diagnosis of COPD, asthma, and ACO initially requires
Asthma, Asthma-COPD Overlap ... = asthma-COPD overlap ... ACOPD #Asthma #Overlap