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hematology algorithm oncology causes secondary management mds pruritus systemic aplastic cancer cardiology infectiousdiseases myelodysplasia platelets primary
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
): • Acute infection ... malignancies • Anemia ... vera (PV) • Myelodysplastic ... syndrome • Myelofibrosis ... Chronic myeloid leukemia
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Syndrome (MD) - ... transformation to acute ... leukemia Management ... #Syndrome #MDS ... #treatment #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Syndromes (MDS) ... syndromes are a ... isoniazid) • Antibiotics ... blood count with differential ... #Syndromes #diagnosis
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Differential Diagnosis ... • Lymphoma • Leukemia ... Throbocythemia • Myelodisplastic ... syndrome Psychiatric ... #dermatology #Differential
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... Diagnosis Algorithm ... hemolysis, deficiency anemia ... Rebound effect from treatment ... Kawasaki, Nephrotic syndrome
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
• Lymphoma • Leukemia ... Throbocythemia • Myelodisplastic ... syndrome Psychiatric ... secondary #systemic #generalized ... #dermatology #Differential
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
- Overview Who ... Constitutional Syndromes ... Constitutional Syndromes ... marrow-failure syndromes ... syndrome (MDS)
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Leukemias Overview ... develop leukostasis syndrome ... - infiltrates (anemia ... • Tumor lysis syndrome ... #Diagnosis
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
Endocarditis - Overview ... Culture Positive: • Acute ... Generalized: Chills ... Cholesterol emboli syndrome ... • IV antibiotics
Myelodysplastic syndromes current treatment algorithm 2018. From Blood Cancer Journal, Published 24 May 2018 Myelodysplastic syndromes (MDS) are
syndromes current ... syndromes (MDS) ... clonal evolution to acute ... myeloid leukemia ... median age at diagnosis
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