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diagnosis hematology oncology anemia aplastic chronic cll infant lp lymphocytic pediatrics risk stepbystep stratification bloodstream cancer catheter crbsi differential differentiation
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Leukemias Overview ... Headaches, bone pain, fever ... develop leukostasis syndrome ... smear: Blasts APML ... • Tumor lysis syndrome
Suspected catheter-related bloodstream infection - Management Algorithm • Temperature 37.8 C • Rigors
- Management Algorithm ... Antibiotic Management ... • Persistent fever ... Hernodynamically stable after treatment ... #Management #Algorithm
“Step by Step” – the new kid on the block – aims to risk stratify this
investigations and treatments ... serious bacterial infections ... #Pediatrics #Peds ... #Febrile #Infant ... #LP #Antibiotics
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
: • Recurrent infections ... (transfusions, antibiotics ... if neutropenic fever ... to MDS or acute leukemia ... #treatment #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Subacute-Acute: • Common: fever ... Rare: DAH, acute febrile ... Differential Diagnosis: Infection ... #management #hematology
The Febrile Infant Step-by-Step Algorithm This is an algorithm developed by European emergency physicians to identify low-risk
The Febrile Infant ... treatment. http ... Diagnosis #EBM #Management ... #Pediatrics #Peds ... Stratification #Fever
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphadenopathy • Fevers ... weeks without infection ... microglobulin Treatment ... • Richter’s Syndrome ... • Sezary syndrome
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia - Overview ... - β-lactam antibiotics ... virus (EBV) • Leukemia ... aplastic anemia Treatment ... #diagnosis #management
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
CLL) - Summary Overview ... ) B symptoms → fevers ... Complications: 1) Infection ... #oncology #hematology ... hemeonc #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... acute or subacute febrile ... following: • Fever ... rapidly, and empiric antibiotic ... #treatment #hematology
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