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management rheumatology anemia druginduced intravascular sle syndrome aplastic comparison dermatology dic differential dil disseminated erythematosus extravascular hemolysis hemolytic oncology sapho
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
(DIC) Overview ... venipuncture sites Laboratory ... Treat primary cause ... #diagnosis #causes ... #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... intravascular coagulation ... usually IgG) (e.g. lupus ... Drugs (Beta lactam antibiotics ... #hematology #anemia
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... versus DIL • Laboratory ... Positive in 60-80% of cases ... life-threatening • Treatment ... Erythematosus #Diagnosis
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
calcium-b) • Laboratory ... Discontinuation of causal ... versus DIL • Laboratory ... life-threatening • Treatment ... #diagnosis #management
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
Rule out other causes ... other etiology • Laboratory ... and lower jaw Treatment ... syndrome with acne: antibiotics ... #Dermatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia - Overview ... and petechiae Causes ... - β-lactam antibiotics ... aplastic anemia Treatment ... #diagnosis #management
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
calcium-b) • Laboratory ... constitutional symptoms • Treatment ... Discontinuation of causal ... #DIL #rheumatology ... #diagnosis #treatment
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome Overview ... Hypocomplementemia • Can cause ... Nephrogenic DI Hematologic ... Adenocarcinoma Treatment ... lubricants • Pharmacologic
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