10 results
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Overview What ... Renal tubular acidosis ... #Syndrome #diagnosis ... #nephrology #management ... #pathophysiology
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Hypokalemia - Differential ... Diagnosis Algorithm ... • Metabolic acidosis ... Bartter syndrome, Gitelman ... potassium #low #nephrology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Pathophysiology ... H+ secretion → Hypokalemia ... Metabolic alkalosis ... #Syndrome #Pathophysiology ... #nephrology #diagnosis
Hypokalemia Differential Algorithm
Acidosis
 - RTA
 - Diarrhea
pH Normal 
 1. Decreased Mg 
 2. Intracellular Shift
Hypokalemia Differential ... Algorithm Acidosis ... Metabolic alkalosis ... #Diagnosis #Causes ... #Workup #Nephrology
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
- Metabolic Alkalosis ... Bartter syndrome, Gitelman ... - Metabolic acidosis ... #diagnosis #Algorithm ... differential #potassium #nephrology
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Urinary Chloride Algorithm ... Bartter syndrome, Gitelman ... Chloride #urine #Algorithm ... #nephrology #differential ... #diagnosis
Causes of Hypokalemia - Differential Diagnosis Algorithm
Defining the cause of hypokalemia starts by measuring urinary K
- Differential Diagnosis ... Algorithm Defining ... Renal tubular acidosis ... Bartter's syndrome, Gitelman's ... #nephrology #potassium
Causes of Hyponatremia - Differential Diagnosis Algorithm
Hypovolemia, UNa > 20: 
 • Renal losses, Diuretic excess,
- Differential Diagnosis ... Algorithm Hypovolemia ... with renal tubal acidosis ... and metabolic alkalosis ... #nephrology
Causes of Hypokalemia
Transcellular Shifts:
 - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
Transcellular Shifts: - Alkalosis ... Renal tubular acidosis ... diuretic use), Gitelman's ... #differential #diagnosis ... #nephrology
Citrate Anticoagulation Toxicity

Hypernatremia (HyperNa):
 - Citrate solutions may have ↑ sodium content and should be paired
circulation → ↓Mg Hypocalcemia ... Anion-Gap Metabolic Acidosis ... metabolism Metabolic alkalosis ... Toxicity #toxicology #nephrology ... #diagnosis