49 results
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Overview What ... thiazide-sensitive sodium ... (renal potassium ... Syndrome #diagnosis #nephrology ... #management #pathophysiology
Algorithm for Differentiating Gitelman syndrome from Bartter syndrome
 • Urine Chloride
 • Urine Ca/Cr ratio

Dr. Krithika
Algorithm for Differentiating ... Gitelman syndrome ... krithicism #Gitelman ... syndrome #Bartter #Algorithm ... #nephrology #hypokalemia
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Pathophysiology ... thiazide-sensitive sodium-chloride ... H+ secretion → Hypokalemia ... #Syndrome #Pathophysiology ... #nephrology #diagnosis
Hypokalemia Differential Diagnosis Algorithm

Low intake 
• poor oral intake 

Renal loss 
• Medication 
• Hypomagnesemia 
•
Diagnosis Algorithm ... oral intake Renal ... Nonreabsorbable anions • Renal ... tubular acidosis • Gitelman's ... Differential #Diagnosis #Algorithm
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Hypokalemia - Differential ... Diagnosis Algorithm ... Extra-renal Losses ... Bartter syndrome, Gitelman ... potassium #low #nephrology
Localization of Renal Tubular Defects
Fanconi Syndrome: Proximal tubule
Bartter Syndrome: Thick ascending loop of Henle
Gitelman Syndrome: Distal
Localization of Renal ... loop of Henle Gitelman ... Fanconi #Bartter #Gitelman ... Nephron #Defects #Pathophysiology ... #Nephrology
Hypokalemia - Differential Diagnosis Algorithm

Transcellular Shift:
 • Alkalosis
 • ↑ beta-2 adrenergic simulation 
 • Erythropoiesis
Diagnosis Algorithm ... Medications Renal ... Losses Non-renal ... Differential #Diagnosis #Algorithm ... #nephrology #low
Causes of Hypokalemia - Differential Diagnosis Algorithm
Defining the cause of hypokalemia starts by measuring urinary K
Differential Diagnosis Algorithm ... gastrointestinal K loss • Renal ... • Renal tubular ... Bartter's syndrome, Gitelman's ... #causes #nephrology
Renal Tubular Acidosis - Diagnosis Algorithm
 • Hyperkalemic Type 4 RTA
 • Hypokalemic Type 1 RTA
Renal Tubular Acidosis ... - Diagnosis Algorithm ... Type 4 RTA • Hypokalemic ... Acidosis #Diagnosis #Algorithm ... #nephrology
Hypomagnesemia - Differential Diagnosis
Renal Causes of Hypomagnesemia - Familial:
Bartter syndrome and Gitelman syndrome, Isolated recessive hypomagnesemia,
Differential Diagnosis Renal ... Bartter syndrome and Gitelman ... with secondary, hypocalcemia ... hypomagnesemia Renal ... diagnosis #causes #nephrology