8 results
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
Oral anticoagulant ... Clotmaster #VTE #DOAC ... Dabigatran #Apixaban #Rivaroxaban ... #Loading #DVT #Pharmacology ... #Hematology
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
algorithm for the treatment ... , edoxaban and rivaroxaban ... direct-acting oral ... for appropriate dosing ... Anticoagulation #Management #Hematology
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
anticoagulant treatment ... Apixaban, Edoxaban or Rivaroxaban ... #Oral #anticoagulant ... #hematology #management ... #pharmacology
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
) Cancer-treatment ... Rivaroxaban and ... Chemotherapy #Oncology #Hematology ... #Interactions #Table ... #Pharmacology
Xa Inhibitors - Apixaban and Rivaroxaban 
Oral Xa inhibitors are recommended by CHEST as first-line for
Oral Xa inhibitors ... patients with VTE treatment ... Here is an overview ... of the dosing schemes ... #Dosing #Pharmacology
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
direct acting oral ... clearance (calculated using ... table ... Apixaban, Edoxaban, Rivaroxaban ... #pharmacology #
Managing warfarin INR

Warfarin dosage must be individualized according to the patient's response to the drug, and
#treatment #medications ... #table #pharmacotherapy ... #decisionaid #cardiology ... #hematology #warfarin ... #dosing
It is important to recognize Acute Decompensated Heart Failure (ADHF) as more than just simply a
then be excreted using ... transitioning to oral ... algorithm #management #cardiology ... #treatment #table ... icu #clinical #pharmacology