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Dermatological semiology of Cutaneous Vasculitis 

Clinicopathologic correlations
 • Purpura, papules, pustules, necrosis: involvement of small vessels
Identification of causes ... Connective tissue disease ... dermatology #semiology #signs ... #lesions #diagnosis ... #clinical #manifestations
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Differential Diagnosis ... tract, and often causes ... to exclude are infections ... Presentation - Systemic Symptoms ... purpura: strong sign
Suspected Celiac Disease - Diagnosis Algorithm

Celiac disease suspected:
 • Signs and symptoms of celiac disease
 •
- Diagnosis Algorithm ... suspected: • Signs ... and symptoms of ... without discernable cause ... Matthew Ho, MD PhD
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... : • Clinical triad ... • Autoimmune diseases ... Labs/Diagnosis:
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... Cold Agglutinin Syndrome ... Clinical Presentation ... (Cold-induced symptoms ... Diagnosis: • hemolytic
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Diagnosis Framework ... Presentation: Systemic Symptoms ... purpura: Strong sign ... • Progressive symptoms ... tract, and often causes
Hematuria - Differential Diagnosis Framework

Gross Hematuria: Red/Dark urine
 • 1ml blood/liter urine can induce color change
basement membrane disease ... hematuria • Signs ... GN or vasculitis ... of glomerular disease ... Hematuria: • Infection
Causes of Peripheral and Central Vertigo
PERIPHERAL VERTIGO
1. Benign paroxysmal positional vertigo (BPPV) - Short-lived (typically less
history of viral infection ... (Wallenberg's syndrome ... Syndrome usually ... varying neurologic signs ... #differential #diagnosis
BEE Syndromes - Non-inflammatory Causes

Immune-mediated conditions affecting the Brain, Eye, and Ear

Visual or auditory symptoms in
Non-inflammatory Causes ... Visual or auditory symptoms ... conjunction with symptoms ... • Lyme disease ... MRI lesions and clinical
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
, small-vessel vasculitis ... association • M > F Clinical ... meningitis), MCC CNS symptoms ... (Clinical Dx). ... #signs #symptoms