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diagnosis differential rheumatology pain approach arthritis autoimmune biliary cirrhosis conditions disorders eosinophil eosinophilia erythematosus extrarticular gca giantcell headache hepatology lupus
Approach to Joint Pain History: Is the pain from: • Joint • Adjacent bursa • Tendon • Ligament • Bone • Muscle • Referred from
or nerve root Symptoms ... experienced briefly (e.g ... alterations (e.g ... subchondral bone (e.g ... derangements (e.g
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Associated with Joint ... Bacterial or viral infection ... disease, Vasculitis (e.g ... ., PAN) • Seizures ... differential #diagnosis #rheumatology
Primary Biliary Cirrhosis - Diagnosis Algorithm Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort Signs: Jaundice, Xanthelasmata, Hepatomegaly Associated history:
quadrant discomfort Signs ... autoimmune disease (e.g ... Raynaud's phenomenon, arthritis ... specific ANAs (e.g ... #hepatology
Approach to Headaches - Differential Diagnosis Algorithm Red flags (PHANTOMS): • Pattern change, progressively worse, papilledema •
) • Systemic symptoms ... and signs (e.g. ... (e.g., meningitis ... ) • Temporal arteritis ... Matthew Ho, MD PhD
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Disorders Testing Algorithm ... workup for specific symptoms ... organ-specific signs ... or symptoms (eg ... Differential #diagnosis #hematology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
systemic sx + signs ... not be subtle e.g ... E.g. 80 yo ESR cutoff ... GCA #Temporal #Signs ... #Symptoms #Diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Malignancy (e.g ... . hematologic) ... Endocrine disorders (e.g ... : • Joint pain ... Induced Lupus: • Symptoms
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Presentation: Systemic Symptoms ... purpura: Strong sign ... vesicular eruption • Joints ... • Progressive symptoms ... Palpable purpura, joint
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Aldolase levels • EMG ... papules and Gottron sign ... ) • Shawl sign ... Syndrome: Fever, joint ... • Nonerosive arthritis
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