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diagnosis treatment algorithm arteritis cardiomyopathy chagas differential disease eosinophil eosinophilia erythematosus gca giantcell hemeonc hemophagocytic hlh leukostasis lupus lymphohistiocytosis lysis
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... workup for specific symptoms ... organ-specific signs ... or symptoms (eg ... Differential #diagnosis #hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
, dyspnea, +/- CXR ... WBC >100k, + lab signs ... unless worrisome EKG ... TLS #diagnosis #management ... #hematology
Chagas Disease - American Trypanosomiasis - Diagnosis and Management Summary Chagas disease (American trypanosomiasis) is an infectious
Diagnosis and Management ... Romana's sign ... /symptoms, positive ... 20-90%, normal ECG ... Cardiomyopathy: Conduction disorders
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
fibromyalgia) • Infections ... • Malignancy (e.g ... (e.g. thyroid disease ... vein thrombosis Hematologic ... Induced Lupus: • Symptoms
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
systemic sx + signs ... not be subtle e.g ... E.g. 80 yo ESR cutoff ... GCA #Temporal #Signs ... #Management
Pheochromocytoma - Diagnosis and Management Summary 10 percent rule = 10% of pheochromocytomas are extra-adrenal, multiple, bilateral,
and Signs: 50% ... and signs: • ... leukocytosis, psychiatric disorders ... diagnostic procedures (eg ... colonoscopy), induction
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
(e.g., EBV) ... and Symptoms: ... pro-inflammatory cytokines (e.g ... Immunosuppression (e.g ... anti-IFN-γ antibodies (e.g
Peripartum Cardiomyopathy (PPCM) What is PPCM? • A form of acute systolic heart failure that develops late in
• Hypertensive disorders ... of pregnancy (e.g ... Genetic variants (e.g ... deficiencies (e.g ... Consider biomarkers (e.g
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