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hematology differential management syndrome algorithm leukemia symptoms approach chronic classification cll crisis dermatology features hospitalization leukostasis lymphocytic lysis mastoiditis mds
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential Diagnosis ... Blood Loss • Acute ... Deficiency • Aplastic ... #Differential #Diagnosis ... #Algorithm #Causes
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... - Differential Diagnosis ... • Marrow Aplasia ... Normal RBCs • Acute ... #Algorithm #Causes
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... and petechiae Causes ... #Anemia #oncology ... #hematology #diagnosis
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... old, ~10,000 new cases ... cytopenias (usually anemia ... transformation to acute ... treatment #hematology #oncology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... count cause hyperviscosity ... - ACS, AKI, acute ... >100k, + lab signs ... Syndrome #TLS #diagnosis
Features of a Sickle Cell Crisis Sickle-cell disease - an autosomal recessive blood disorder. Characterized by red
The underlying pathophysiology ... ischaemia. 2) Aplasia ... - Acute worsening ... of the baseline anaemia ... Crisis #Features #Signs
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... • Neutropenia, anemia ... Pure red cell aplasia ... ’s lymphoma or acute ... #workup #oncology
Anemia of Hospitalization - Pathophysiology Why does the Hgb/Hct drop in the first two days during hospitalization? Interestingly,
- Pathophysiology ... blood loss or acute ... of unnecessary diagnostic ... #pathophysiology ... #differential #diagnosis
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... count ↑ PLT • ↑ PBS ... - infiltrates (anemia ... Leukemia #Hematology #Oncology ... #Diagnosis
Mastoiditis: Pathogenesis and clinical findings Acute or Chronic Otitis Media -> Stage 1: Hyperemeia of the mastoid
clinical findings Acute ... hearing loss, nausea ... #Mastoiditis #pathophysiology ... #signs #symptoms ... #diagnosis #otology
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