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diagnosis management neurology hematology differential barre leukemia oncology cauda caudaequina chronic cll crisis equina gap gbs globulin gravis guillainbarre leukostasis
Guillain-Barre Syndrome - Summary Acute AIDP that presents with rapidly progressive flaccid weakness Epidemiology: • 1-2 cases/100,000 per
Guillain-Barre Syndrome ... - Summary Acute ... Epidemiology: • 1-2 cases ... Pathophysiology ... - NORMAL CSF WBC
Etiologies of Peripheral Neuropathy • Metabolic / Nutritional: DiabetesB12 deficiency, Uremia/ESRD, Hypothyroidism • Medication-induced: ART, Antibiotics,
Inflammatory/AI: CIDP, Guillain-Barre ... Paraprotein-associated (POEMS syndrome ... Fabry's disease, Acute ... differential #diagnosis #causes ... #neurology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... count cause hyperviscosity ... - ACS, AKI, acute ... >100k, + lab signs ... : • Pathophysiology
Cauda Equina Syndrome Overview Cauda Equina Syndrome: • Prevalence: 1:33,000-100,000 ppl/yr • Incidence: 1.5-3.4 million ppl/yr •
spine • MCC- acute ... - Emergency Causes ... Tethered cord • Guillain-Barre ... differential #diagnosis #causes ... #neurology
Guillain-Barré Syndrome (GBS) Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness Epidemiology: • Incidence: 1
Guillain-Barré Syndrome ... (GBS) Acute autoimmune ... Incidence: 1 to 2 cases ... the underlying pathophysiology ... #Barre #Syndrome
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
Miller Fischer and PCB ... test - Cogan sign ... - Peek sign ... aspiration and acute ... diagnosis #management #neurology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... Lymphocytosis on CBC ... • Neutropenia, anemia ... • Richter’s Syndrome ... ’s lymphoma or acute
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... count ↑ PLT • ↑ PBS ... develop leukostasis syndrome ... - infiltrates (anemia ... • Tumor lysis syndrome
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... Viral infections (acute ... autoimmune hepatitis, PBC ... Thalassemia, Sickle cell anemia ... inflammation (acute
Scleroderma Renal Crisis (SRC) Clinical Presentation of Scleroderma Renal Crisis: 1) Acute kidney injury 2) Abrupt onset of hypertension 3)
Renal Crisis: 1) Acute ... microangiopathic hemolytic anemia ... (MAHA) Pathophysiology ... Renal #Crisis #rheumatology ... #nephrology #diagnosis
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